α-D,L-Sorbose

Pharmacokinetics of orally administered DL-α-lipoic acid in dogs.

OBJECTIVE To determine the pharmacokinetics of DL-α-lipoic acid in dogs when administered at 3 dosages via 3 methods of delivery. ANIMALS 27 clinically normal Beagles. PROCEDURES In a 3 × 3 factorial Latin square design, 3 dosages (2.5, 12.5, and 25 mg/kg) of DL-α-lipoic acid were administered orally in a capsule form and provided without a meal, in a capsule form and provided with a meal, ...

Phenotypic Assay on L - Sorbose

BIOCHEMISTRY. For the article ‘‘Kernel energy method: Application to insulin,’’ by Lulu Huang, Lou Massa, and Jerome Karle, which appeared in issue 36, September 6, 2005, of Proc. Natl. Acad. Sci. USA (102, 12690–12693; first published August 24, 2005; 10.1073 pnas.0506378102), the authors note an error in a funding acknowledgment: ‘‘L.M. thanks the National Institutes of Health for National In...

Kinetic studies on sorbose fermentation.

NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.

The NADPH-dependent L-sorbose reductase (SR) of L-sorbose-producing Gluconobacter suboxydans IFO 3291 contributes to intracellular L-sorbose assimilation. The gene disruptant showed no SR activity and did not assimilate the once-produced L-sorbose, indicating that the SR functions mainly as an L-sorbose-reducing enzyme in vivo and not as a D-sorbitol-oxidizing enzyme.

L-sorbose reductase and its transcriptional regulator involved in L-sorbose utilization of Gluconobacter frateurii.

Upstream of the gene for flavin adenine dinucleotide (FAD)-dependent D-sorbitol dehydrogenase (SLDH), sldSLC, a putative transcriptional regulator was found in Gluconobacter frateurii THD32 (NBRC 101656). In this study, the whole sboR gene and the adjacent gene, sboA, were cloned and analyzed. sboR mutation did not affect FAD-SLDH activity in the membrane fractions. The SboA enzyme expressed an...